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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [ChIP-seq]

ABSTRACT: Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [ChIP-seq]

PROVIDER: PRJNA828521 | ENA |

REPOSITORIES: ENA

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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [RNA-seq]

Project description:To understand the role of TH target genes in BAT, we developped a murine transgenic model in which TH signaling is selectively lost in BAT (BATKO mice). After establishing TH target genes in BAT, we used BATKO mice to understand which pathways were controlled by TH in BAT during metabolic stressors, i.e., cold and high-fat diet (HFD)

2022-04-29 | GSE201135 | GEO

Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [ChIP-seq]

Project description:To understand the role of TH target genes in BAT, we developped a murine transgenic model which expressed a tagged-form of the thyroid hormone receptor alpha (TRa1, tagged with GS which is a fusion between protein G and streptavidin) specifically in brown adipocytes. Combined with RNAseq data, it allowed to establish the direct target genes of thyroid hormones (TH) in brown adipocytes

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Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors

Project description:Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors

| PRJNA828537 | ENA

Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [RNA-seq]

Project description:Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [RNA-seq]

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Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation

Project description:The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment of T3, the active form of TH, increases the recruitment of thermogenic capacity in interscapular BAT of male mice through hyperplasia by promoting the TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals the heterogeneous nature and hierarchical trajectory within adipocyte progenitor cellsof interscapular BAT. Further analyses suggest that T3 facilitates cell state transition from a more stem-like state towards a more committed adipogenic state and promotes cell cycle progression towards a mitotic state in adipocyte progenitor cells, through mechanisms involving the action of Myc on glycolysis. Our findings elucidate the mechanisms underlying the TH action in adipocyte progenitors residing in BAT and provide a framework for better understanding of the TH effects on hyperplastic growth and adaptive thermogenesis in BAT depot at a single-cell level.

2022-05-13 | GSE186188 | GEO

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver

Project description:This SuperSeries is composed of the following subset Series: GSE16017: Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part B GSE16018: Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C GSE16074: Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A Refer to individual Series

2010-05-16 | E-GEOD-16075 | biostudies-arrayexpress

Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-27 | GSE201136 | GEO

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A

Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: cell cycle design,co-expression design,reference design,time series design Thyroid hormone (TH) controls remodeling of the pancreas. The micro array was carried out to identify changes in gene expression between the tadpole and frog pancreas. This is part 1, done on the 44K Xenopus platform. This dataset was used only for one pancreas experiment with several data points (control, 12h, 24h, 48h and frog). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.

2010-05-16 | E-GEOD-16074 | biostudies-arrayexpress

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part B

Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: co-expression design,development or differentiation design,reference design,time series design Overall design: Thyroid hormone (TH) controls remodeling of the liver. The microarray was carried out to identify changes in gene expression at different stages of development during metamorphosis. This is part 2, done on the 22K Xenopus platform version 1. This dataset was from livers of Xenopus tadpoles (NF52, NF62, and NF66). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.

2010-05-16 | E-GEOD-16017 | biostudies-arrayexpress

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C

Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: co-expression design,development or differentiation design,reference design,time series design Overall design: Thyroid hormone (TH) controls remodeling of the pancreas. The microarray was carried out to identify changes in gene expression at different stages of development during metamorphosis.. This is part 3, done on the 22K Xenopus platform version 2. This dataset was from pancreas of Xenopus tadpoles (NF52, NF62, and NF66). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.

2010-05-16 | E-GEOD-16018 | biostudies-arrayexpress

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