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3D chromatin organization involving MEIS1 factor in the cis-regulatory landscape of GJB2

ABSTRACT: 3D chromatin organization involving MEIS1 factor in the cis-regulatory landscape of GJB2

PROVIDER: PRJNA830351 | ENA |

REPOSITORIES: ENA

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3D Chromatin Organization Involving MEIS1 Factor in the <i>cis</i>-Regulatory Landscape of <i>GJB2</i>.

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3D chromatin organization involving MEIS1 factor in the cis-regulatory landscape of GJB2

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A map of cis-regulatory elements and 3D genome structures in zebrafish

Project description:The zebrafish has been widely used for the study of human disease and development, as ~70% of the protein-coding genes are conserved between the two species. Annotation of functional control elements of the zebrafish genome, however, has lagged behind that of other model systems such as mouse and Drosophila. Based on multi-omics approaches taken in the ENCODE and Roadmap Epigenomics projects, we performed RNA-seq, ATAC-seq, ChIP-seq and Hi-C experiments in ten adult and two embryonic tissues to generate a comprehensive map of transcriptomes and regulatory elements in the zebrafish Tuebingen reference strain. Overall, we have identified 235,596 cis-regulatory elements, which potentially shape the tissue-specific and developmental-stage-specific gene expression in zebrafish. A comparison of zebrafish, human, and mouse regulatory elements allowed us to identify both evolutionarily conserved and species-specific regulatory sequences. Furthermore, through the analysis of Hi-C data in zebrafish brain and muscle, we observed different levels of 3D genome organization, including compartment, topological associating domains (TADs), and chromatin loops in zebrafish. A subset of TADs are deeply conserved between zebrafish and human. This work provides an additional epigenomic anchor for the functional annotation of vertebrate genomes and the study of evolutionally conserved elements of 3D genome organization.

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