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Transcriptome-wide impact of food-restriction on the medio-basal hypothalamus of the ewe.

ABSTRACT: Transcriptome-wide impact of food-restriction on the medio-basal hypothalamus of the ewe.

PROVIDER: PRJNA835496 | ENA |

REPOSITORIES: ENA

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Transcriptome-wide impact of food-restriction on the medio-basal hypothalamus of the ewe.

Project description:Here we used RNAseq to compare the transcriptomes of ewes fed ad libitum VS food-restricted ewes (hereafter AL and RES, respectively). Body Condition Score was used as an index to validate the impact of food restriction.

2022-05-12 | GSE202346 | GEO

Transcriptome-wide impact of progesterone in the medio-basal hypothalamus of the ewe

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Project description:Here we used RNAseq to assess the impact of progesterone (P4) on the transcriptome of the medio-basal hypothalamus of ewes. Ewes were treated with a vaginal fluogestone acetate sponge in mid-February. The sponge was removed in early March and ewes received a PMSG injection. Animals were then killed either 2 days (follicular phase) or 12 days (luteal phase) later.

2022-05-12 | GSE202508 | GEO

Transcriptome-wide impact of season and progesterone in the medio-basal hypothalamus of the goat

Project description:Here we used RNAseq to compare the transcriptomes of the medio-basal hypothalamus of goats killed at two different times of the year (end of January and mid-May) and under different hormonal conditions (follicular and luteal phase, in January only). The current experiment was designed to identify the impact of photoperiod upon the transcriptome and to compare it with that of the ewe. The current design also tested the potential impact of progesterone (P4) upon this transcriptome; ewes were treated with a vaginal fluogestone acetate sponge during the breeding season (January) and killed either 2 days (follicular phase) or 8 days (luteal phase) after estrumate treatment and sponge removal.

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Project description:Using NGS, we report the impact of chronic stress on the transcriptome of the dorsal and ventral hippocampus in the ewe. This study identifies specific transcriptional signatures of the dorsal VS ventral hippocampus (>220 DEG) and demonstrates a very limited transcriptional impact of stress, exclusively restricted to the dorsal hippocampus (<10 DEG).

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Sex-specific resilience of neocortex to food restriction

Project description:Mammals have evolved sex-specific adaptations to reduce energy usage in times of food scarcity. These adaptations are well described for peripheral tissue, though much less is known about how the energy-expensive brain adapts to food restriction, and how such adaptations differ across the sexes. Here, we examined how food restriction impacts energy usage and function in the primary visual cortex (V1) of adult male and female mice. Molecular analysis and RNA sequencing revealed that food restriction modulated canonical, energy-regulating pathways including oxidative phosphorylation, AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling, significantly in males but not in females V1. Moreover, we found that in contrast to males, food restriction in females non-significantly affected V1 ATP usage and visual coding precision (assessed by orientation selectivity). Decreased serum leptin is necessary for triggering energy-saving changes in male mouse V1 during food restriction. Consistent with this result, we found a significant decrease of serum leptin in food-restricted males but no significant change in food-restricted females. Collectively, our findings demonstrate that cortical function and energy usage in female mice are more resilient to food restriction than in males. The neocortex, therefore, contributes to sex-specific, energy-saving adaptations in response to metabolic challenge.

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Leptin and the Placental Response to Maternal Food Restriction during Early Pregnancy

Project description:Concentrations of leptin decline during food restriction. This study was designed to test the hypothesis that some of the effects of maternal food restriction on placental development are mediated by the loss of leptin. Mice were randomized to 3 treatment groups on day 1.5 of pregnancy: (1) ad libitum fed (control) (2) 50% food restriction (restricted) (3) 50% food restriction with leptin replacement (1Âµg/g body weight/day) (leptin). On day 11.5 placentas were collected, and two placentas from each mother were pooled for microarray analysis.

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