Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: PGA Rat Liver Methylprednisolone

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA85181 | ENA |

REPOSITORIES: ENA

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Publications

Pharmacodynamic modeling of acute and chronic effects of methylprednisolone on hepatic urea cycle genes in rats.

Hazra Anasuya A   DuBois Debra C DC   Almon Richard R RR   Snyder Grayson H GH   Jusko William J WJ  

Gene regulation and systems biology 20080214


Corticosteroids (CS) regulate many enzymes at both mRNA and protein levels. This study used microarrays to broadly assess regulation of various genes related to the greater urea cycle and employs pharmacokinetic/pharmacodynamic (PK/PD) modeling to quantitatively analyze and compare the temporal profiles of these genes during acute and chronic exposure to methylprednisolone (MPL). One group of adrenalectomized male Wistar rats received an intravenous bolus dose (50 mg/kg) of MPL, whereas a second  ...[more]

Publication: 1/2

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