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Establishment of radioresistant U87MG glioblastoma cell line

ABSTRACT: Establishment of radioresistant U87MG glioblastoma cell line

PROVIDER: PRJNA853300 | ENA |

REPOSITORIES: ENA

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Establishment of radioresistant U87MG glioblastoma cell line

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Inhibition of Mitochondria NADH–Ubiquinone Oxidoreductase (Complex I) Sensitizes the Radioresistant Glioma Cells to Radiation

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Expression data from U87MG subclones

Project description:U87MG is a glioblastoma cell line that shows substantial heterogeneity despite long-term passaging. We used microarrays to identify variations in gene expression that are associated with phenotypic differences among subclones derived from U87MG.

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Gene expression data in U87MG cell line transfected with miR-490 overexpression vector PC-490 or its control PCDNA3.1 (+).

Project description:miR-490 is robustly downregulated in GBM tumour samples. This study identifies the genes differentially expressed upon miR-490 overexpression in U87MG glioblastoma cell line. GeneChip PrimeView Human Gene Expression Array was used to assess mRNA expression profile in response to miR-490 overexpression in U87MG cell line.

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Transcriptome analysis of CD133 overexpressed U87MG glioblastoma cells

Project description:This study investigated the biological function of CD133 by ectopic expression of CD133 in U87MG cell line. Although CD133 is widely used as a cancer stem cell marker, there are a few studies that examined its own biological functions. While a number of loss-of-function studies about CD133 have shown that CD133 have effects on cancer progression, there are few gain-of-function studies about functions of CD133. Thus, we identified the potential function of CD133 by its overexpression in U87MG glioblastoma cell line. Though there were no significant changes in cell growth and sphere forming ability, elevated IL-1β and its downstream chemokines (CCL3, CXCL3, CXCL5) may function as chemoattractants which affect recruitment of Ly6G+ neutrophils surrounding necrotic regions in vivo and migration of neutrophil-like dHL-60 cells. Taken together, this results imply that CD133 can regulate IL-1β signaling, and promotes the environmental change.

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Transcription profiling array of human glioblastoma cell line U87MG comparing control cells (U87RNAi) with U87shLAPTM5 knockdown cells

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2017-12-07 | E-MTAB-6316 | biostudies-arrayexpress

Transcriptome analysis of ABCB7 overexpressed U87MG glioblastoma cells

Project description:This study investigated the biological function of ABCB7 in U87MG glioblastoma cell line. Many ABC transporters are known contributions to drug resistance and various biological process. However, mitochondrial ABC transporters aren’t known mechanism to control biological process. We identified the potential roles of ATP-binding cassette (ABC) transporter subfamily member 7 (ABCB7), one of the mitochondrial ABC transporters. ABCB7 activates signaling pathway of hypoxia-inducible factor 1 alpha (HIF1α) by hypoxia independent regulation. This signaling pathway regulates the death inhibitory genes and survival related genes. Also, ABCB7 downregulates cell cycle related genes. Our results provide that ABCB7 is essential for the survival of malignant brain tumors.

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RNA sequencing analysis of human glioblastoma cell line U87MG treated with LMO2 overexpression.

Project description:RNA sequencing analysis of human glioblastoma cell line U87MG treated with LMO2 overexpression.

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Transcription factor ZBTB7A-deficiency effect on U87MG cells in vitro

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