Genomics

Dataset Information

0

Caloric restriction


ABSTRACT: caloric restriction

PROVIDER: PRJNA87197 | ENA |

REPOSITORIES: ENA

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Publications

Additive regulation of hepatic gene expression by dwarfism and caloric restriction.

Tsuchiya Tomoshi T   Dhahbi Joseph M JM   Cui Xinping X   Mote Patricia L PL   Bartke Andrzej A   Spindler Stephen R SR  

Physiological genomics 20040519 3


Disrupted growth hormone/insulin-like growth factor-1 signaling (DF) and caloric restriction (CR) extend life span and delay the onset of age-related diseases in rodents. In combination, these interventions additively extend life span. To investigate the molecular basis for these effects, we performed genome-wide, microarray expression analysis of liver from homozygous and heterozygous Ames dwarf mice fed ad libitum or CR. CR and DF additively affected a group of 95 genes. Individually and toget  ...[more]

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