Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Aged F344 rat coronary artery

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA87511 | ENA |

REPOSITORIES: ENA

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Publications

Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries.

Csiszar Anna A   Ungvari Zoltan Z   Koller Akos A   Edwards John G JG   Kaley Gabor G  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030422 9


The phenotypic and functional changes of coronary arteries with aging promote ischemic heart disease. We hypothesized that these alterations reflect an aging-induced proinflammatory shift in vascular regulatory mechanisms. Thus, in isolated coronary arteries of young (3-month-old) and aged (25-month-old) male Fischer 344 rats the expression of 96 cytokines, chemokines, and their receptors were screened by a cDNA-based microarray technique. In aged vessels expressions of tumor necrosis factor (TN  ...[more]

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