Rattus norvegicus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA87603 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included.
2007-10-11 | E-GEOD-665 | biostudies-arrayexpress
Project description:Effect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease
| PRJNA149237 | ENA
Project description:Comparative study of sesame lignans affecting gene expression profile and fatty acid oxidation in rat liver
| PRJNA182737 | ENA
Project description:Influence of Fatty Acid Diets on Gene Expression in Rat Mammary Epithelial Cells
| PRJNA111927 | ENA
Project description:Influence of dietary sucrose and copper content in a rat model of non-alcoholic fatty-liver disease
| PRJNA253783 | ENA
Project description:A series of two color gene expression profiles obtained using Agilent 44K expression microarrays was used to examine sex-dependent and growth hormone-dependent differences in gene expression in rat liver. This series is comprised of pools of RNA prepared from untreated male and female rat liver, hypophysectomized (‘Hypox’) male and female rat liver, and from livers of Hypox male rats treated with either a single injection of growth hormone and then killed 30, 60, or 90 min later, or from livers of Hypox male rats treated with two growth hormone injections spaced 3 or 4 hr apart and killed 30 min after the second injection. The pools were paired to generate the following 6 direct microarray comparisons: 1) untreated male liver vs. untreated female liver; 2) Hypox male liver vs. untreated male liver; 3) Hypox female liver vs. untreated female liver; 4) Hypox male liver vs. Hypox female liver; 5) Hypox male liver + 1 growth hormone injection vs. Hypox male liver; and 6) Hypox male liver + 2 growth hormone injections vs. Hypox male liver. A comparison of untreated male liver and untreated female liver liver gene expression profiles showed that of the genes that showed significant expression differences in at least one of the 6 data sets, 25% were sex-specific. Moreover, sex specificity was lost for 88% of the male-specific genes and 94% of the female-specific genes following hypophysectomy. 25-31% of the sex-specific genes whose expression is altered by hypophysectomy responded to short-term growth hormone treatment in hypox male liver. 18-19% of the sex-specific genes whose expression decreased following hypophysectomy were up-regulated after either one or two growth hormone injections. Finally, growth hormone suppressed 24-36% of the sex-specific genes whose expression was up-regulated following hypophysectomy, indicating that growth hormone acts via both positive and negative regulatory mechanisms to establish and maintain the sex specificity of liver gene expression. For full details, see V. Wauthier and D.J. Waxman, Molecular Endocrinology (2008)
2008-05-24 | GSE11529 | GEO
Project description:Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]
| PRJNA255458 | ENA
Project description: Not available
| S-EPMC9277659 | biostudies-literature
Project description:Bile acid flux is necessary for normal liver regeneration
| PRJNA237324 | ENA
Project description:Luciferase activity screen identifies Oxymatrine regulating obesity-related gene enhancer activity in nonalcoholic fatty liver disease
| PRJNA693665 | ENA