Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Mouse Kidney - Effect of Low Phosphate Diet in Normal and Hyp Mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA87885 | ENA |

REPOSITORIES: ENA

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Publications

The genomic response of the mouse kidney to low-phosphate diet is altered in X-linked hypophosphatemia.

Meyer Martha H MH   Dulde Emily E   Meyer Ralph A RA  

Physiological genomics 20040617 1


The mechanism for the renal adaptation to low-phosphate diets is not well understood. Whether the Hyp mutation of the Phex gene blocks this adaptation is also not clear. To gain further insight into this, 5-wk-old normal and Hyp mice were fed a control (1.0% P) or low-phosphate diet (0.03% P) for 3-5 days. Renal RNA was hybridized to Affymetrix U74Av2 microarrays (5 arrays/group). Of the 5,719 detectable genes on each array, 290 responded significantly (P < 0.01) to low-phosphate diet in normal  ...[more]

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