Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA89521 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Wilms Tumor-1 (WT-1) and its candidate target genes in gliomagenesis
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Project description:Methylome analysis of normal kidney, nephrogenic rest and Wilms tumor
| PRJNA254506 | ENA
Project description:Gene expression analyses through cDNA microarray of unique Wilms tumor (WT) histological components, blastema (BL), epithelia (EP) and stroma (ST), from different patients were performed and compared with non-neoplastic mature and pool of fetal kidney (FK). We used a customized cDNA array containing 4 608 human genes and demonstrated that BL had over representation of genes with similar expression behavior to the earliest stage of normal renal development. Moreover, since WT is a result of loss of developmental control and gain of tumorigenic potential in a successive way, herein we identified genes whose expression level is altered during the kidney development and also in WT and classified as WT-kidney development set. From this set, a smaller group of 36 differentially expressed genes was derived, which was enriched by genes involved in signal transduction, such as APC, BZRP, MET, PLAU, GPR35 and TRADD. An over representation of genes belonging to the WNT signaling pathway were observed. Immunostaining assays of APC and beta-catenin were carried out in 108 specimens showing differential labeling localization in WT. Altogether our data show molecular evidences confirming the recapitulation of embryonic kidney by WT components and strongly suggest that the WNT signaling pathway plays a crucial role in Wilms tumorigenesis. Keywords: Wilms tumor, cDNA microarray, Histological components, WNT signaling pathway
2006-08-01 | GSE4530 | GEO
Project description:The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bead platform.
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
Project description:Downregulation of specific microRNAs contribute to epithelial-mesenchymal transition of Wilms' tumor cancer initiating cells. In order to gain insight into the biology of initiating cells/cancer stem cells (CIC/CSCs) in Wilms' tumor, we compared the microRNA expression profile of un-sorted propagatable WT xenografts (p-WT Xn), p-WT NCAM+ALDH1+-derived Xn and human fetal kidneys (hFKs). Global microRNA expression analysis showed specific microRNAs to differentially express identifying a strong miRNA signature for the NCAM+ALDH1+ WT CICs. 3 different tissue types (described in 'summary') each with n=4 were homoginized and analyzed for their global miRNA expression profiles. Human Fetal Kidney tissues were used as a control.
2012-12-01 | E-GEOD-33332 | biostudies-arrayexpress
Project description:We show that oncogenesis in Wilms’ tumor - the most common pediatric renal cancer- is mediated by small non-coding RNAs miRNAs.Interestingly, several differentially expressed miRNAs target genes that are known to play important role in kidney development. miRNA profile of Wilm's tumor vs. normal kidney with two color microarray protocol
2015-07-01 | E-GEOD-17342 | biostudies-arrayexpress
Project description: Not available
| S-EPMC2531291 | biostudies-literature
Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.
2019-07-31 | GSE114179 | GEO
Project description:Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that over-expression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in pathology highly reminiscent of Wilms tumor.
2014-06-01 | GSE56323 | GEO