Genomics

Dataset Information

0

Drosophila melanogaster


ABSTRACT: Differential gene expression in S284Y flies

ORGANISM(S): Drosophila melanogaster  

PROVIDER: PRJNA90093 | ENA |

REPOSITORIES: ENA

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Publications

Genome-wide analysis reveals an unexpected function for the Drosophila splicing factor U2AF50 in the nuclear export of intronless mRNAs.

Blanchette Marco M   Labourier Emmanuel E   Green Richard E RE   Brenner Steven E SE   Rio Donald C DC  

Molecular cell 20040601 6


The protein factor U2AF is an essential component required for pre-mRNA splicing. Mutations identified in the S. pombe large U2AF subunit were used to engineer transgenic Drosophila carrying temperature-sensitive U2AF large subunit alleles. Mutant recombinant U2AF heterodimers showed reduced polypyrimidine tract RNA binding at elevated temperatures. Genome-wide RNA profiling comparing wild-type and mutant strains identified more than 400 genes differentially expressed in the dU2AF50 mutant flies  ...[more]

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