Dataset Information


Homo sapiens

ABSTRACT: Concurrent Versus Individual Binding of HuR and AUF1 to Common Labile Target mRNAs

ORGANISM(S): Homo sapiens  



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Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.

Lal Ashish A   Mazan-Mamczarz Krystyna K   Kawai Tomoko T   Yang Xiaoling X   Martindale Jennifer L JL   Gorospe Myriam M  

The EMBO journal 20040715 15

RNA-binding proteins HuR and AUF1 bind to many common AU-rich target mRNAs and exert opposing influence on target mRNA stability, but the functional interactions between HuR and AUF1 have not been systematically studied. Here, using common target RNAs encoding p21 and cyclin D1, we provide evidence that HuR and AUF1 can bind target transcripts on both distinct, nonoverlapping sites, and on common sites in a competitive fashion. In the nucleus, both proteins were found together within stable ribo  ...[more]

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