Dataset Information


Rattus norvegicus

ABSTRACT: Effect of Age on Fracture Healing in the Rat: Series 3

ORGANISM(S): Rattus norvegicus  



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Altered expression of mitochondrial genes in response to fracture in old rats.

Meyer Martha H MH   Meyer Ralph A RA  

Acta orthopaedica 20061201 6

BACKGROUND: Old rats require more time for bone to bridge a fracture gap than young rats. To explore possible mitochondrial dysfunction in this delay, we measured levels of mRNA derived from mitochondrial genes in healing fractures of young, adult, and old rats. METHODS: Diaphyseal femoral fractures were induced in female rats at 6, 26, and 52 weeks of age (young, adult, and old rats, respectively). At baseline, at 3 days, and 1, 2, 4, and 6 weeks after fracture, the fracture site was harvested.  ...[more]

Publication: 1/4

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