Genomics

Dataset Information

0

Mus musculus


ABSTRACT: IL10-/-DC + 0,SEA,LPS,SEA/LPS 6H

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA90169 | ENA |

REPOSITORIES: ENA

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Publications

Helminth antigens modulate TLR-initiated dendritic cell activation.

Kane Colleen M CM   Cervi Laura L   Sun Jie J   McKee Amy S AS   Masek Katherine S KS   Shapira Sagi S   Hunter Christopher A CA   Pearce Edward J EJ  

Journal of immunology (Baltimore, Md. : 1950) 20041201 12


There is increasing awareness that helminth infections can ameliorate proinflammatory conditions. In part, this is due to their inherent ability to induce Th2 and, perhaps, regulatory T cell responses. However, recent evidence indicates that helminths also have direct anti-inflammatory effects on innate immune responses. In this study, we address this issue and show that soluble molecules from the eggs of the helminth parasite Schistosoma mansoni (SEA) suppress LPS-induced activation of immature  ...[more]

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