Dataset Information


Mus musculus

ABSTRACT: Comparison of conventional and germ-free gastrointestinal tract

ORGANISM(S): Mus musculus  



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Impact of commensal microbiota on murine gastrointestinal tract gene ontologies.

Mutch David M DM   Simmering Rainer R   Donnicola Dominique D   Fotopoulos Grigorios G   Holzwarth James A JA   Williamson Gary G   Corthésy-Theulaz Irène I  

Physiological genomics 20040629 1

The gastrointestinal tract (GIT) of eukaryotes is colonized by a vast number of bacteria, where the commensal microbiota play an important role in defining the healthy gut. To investigate the influence of commensal bacteria on multiple regions of the host GIT transcriptome, the gene expression profiles of the corpus, jejunum, descending colon, and rectum of conventional (n = 3) and germ-free mice (n = 3) were examined using the Affymetrix Mu74Av2 GeneChip. Differentially regulated genes were ide  ...[more]

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