Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Terminal heart failure

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA90867 | ENA |

REPOSITORIES: ENA

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Publications


About one-half of double transgenic rats (dTGR) overexpressing the human renin and angiotensinogen genes die by age 7 wk of terminal heart failure (THF); the other (preterminal) one-half develop cardiac damage but survive. Our study's aim was to elucidate cardiac gene expression differences in dTGR-THF compared with dTGR showing compensated cardiac hypertrophy but not yet THF. dTGR treated with losartan (LOS) and nontransgenic rats (SD) served as controls. THF-dTGR body weight was significantly  ...[more]

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