Genomics

Dataset Information

0

Primate Comparison Study


ABSTRACT: Primate Comparison Study

PROVIDER: PRJNA91975 | ENA |

REPOSITORIES: ENA

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Publications

Expression profiling in primates reveals a rapid evolution of human transcription factors.

Gilad Yoav Y   Oshlack Alicia A   Smyth Gordon K GK   Speed Terence P TP   White Kevin P KP  

Nature 20060301 7081


Although it has been hypothesized for thirty years that many human adaptations are likely to be due to changes in gene regulation, almost nothing is known about the modes of natural selection acting on regulation in primates. Here we identify a set of genes for which expression is evolving under natural selection. We use a new multi-species complementary DNA array to compare steady-state messenger RNA levels in liver tissues within and between humans, chimpanzees, orangutans and rhesus macaques.  ...[more]

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