Project description:Telomere chromatin structure is pivotal for maintaining genome stability by regulating the binding of telomere-associated proteins and inhibition of a DNA damage response. In yeast, the silent information regulator (Sir) proteins bind to terminal telomeric repeats and to subtelomeric X-elements resulting in histone deacetylation and transcriptional silencing. Herein, we show that sir2 mutant strains display a very specific loss of a nucleosome residing in the X-element. Most yeast telomeres contain an X-element and the nucleosome occupancy defect in sir2 mutants is remarkably consistent between different telomeres.

2022-08-09 | GSE195972 | GEO

Saccharomyces cerevisiae alpha factor cell cycle

Project description:Yeast cell cycle microarray to identify global trancription profile. Keywords: cell cycle time course

2006-06-01 | GSE3635 | GEO