Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: reversible and irreversible Thy-1 nephritis

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA92743 | ENA |

REPOSITORIES: ENA

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Publications

Microarray analysis of a reversible model and an irreversible model of anti-Thy-1 nephritis.

Tsuji M   Monkawa T   Yoshino J   Asai M   Fukuda S   Kawachi H   Shimizu F   Hayashi M   Saruta T  

Kidney international 20060301 6


A single intravenous injection of anti-Thy-1 monoclonal antibody (mAb) 1-22-3 is known to cause reversible mesangial proliferative glomerulonephritis. However, mAb 1-22-3 injection followed by unilateral nephrectomy leads to progressive glomerulosclerosis and tubulointerstitial change with an irreversible course. To identify genes that play an important role in the irreversible progression of renal injury, we used microarray technology to identify differences in gene expression between these mod  ...[more]

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