Dataset Information


Saccharomyces cerevisiae

ABSTRACT: Impact of Nonsense-mediated mRNA Decay on the Global Expression Profile of Budding Yeast

ORGANISM(S): Saccharomyces cerevisiae  



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Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast.

Guan Qiaoning Q   Zheng Wei W   Tang Shijie S   Liu Xiaosong X   Zinkel Robert A RA   Tsui Kam-Wah KW   Yandell Brian S BS   Culbertson Michael R MR  

PLoS genetics 20061018 11

Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression. In Saccharomyces cerevisiae, hundreds of endogenous RNA Polymerase II transcripts achieve steady-state levels that depend on NMD. For some, the decay rate is directly influenced by NMD (direct targets). For others, abundance is NMD-sensitive but without any eff  ...[more]

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