Genomics

Dataset Information

0

Toxoplasma gondii


ABSTRACT: Tachyzoite to bradyzoite differentiation

ORGANISM(S): Toxoplasma gondii  

PROVIDER: PRJNA93129 | ENA |

REPOSITORIES: ENA

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Publications

Genetic analysis of tachyzoite to bradyzoite differentiation mutants in Toxoplasma gondii reveals a hierarchy of gene induction.

Singh Upinder U   Brewer Jeremy L JL   Boothroyd John C JC  

Molecular microbiology 20020501 3


Developmental switching in Toxoplasma gondii, from the virulent tachyzoite to the relatively quiescent bradyzoite stage, is responsible for disease propagation and reactivation. We have generated tachyzoite to bradyzoite differentiation (Tbd-) mutants in T. gondii and used these in combination with a cDNA microarray to identify developmental pathways in bradyzoite formation. Four independently generated Tbd- mutants were analysed and had defects in bradyzoite development in response to multiple  ...[more]

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