Saccharomyces cerevisiae
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA93483 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Synthetic circuit identifies subpopulations with sustained memory of DNA damage
| PRJNA152887 | ENA
Project description:Involvement of a chromatin remodeling complex in damage tolerance during DNA replication
| PRJNA120269 | ENA
Project description:Association of Taf14 with acetylated histone H3 directs the DNA damage response and gene transcription
| PRJNA292038 | ENA
Project description:DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity
| PRJNA198487 | ENA
Project description:Chronic Oxidative DNA Damage Due to DNA Repair Defects Causes Chromosomal Instability in Saccharomyces cerevisiae
| PRJNA108227 | ENA
Project description:Asymmetric down-regulation of tolerance to DNA damage at replication forks
| PRJNA354591 | ENA
Project description:The NuA4 complex promotes Translesion Synthesis (TLS) - mediated DNA damage tolerance
| PRJNA276018 | ENA
Project description:DNA damage checkpoint kinases regulate a global network of transcription factors
| PRJNA173726 | ENA
Project description:Decay profiles of Saccharomyces cerevisiae mRNAs following oxidative stress and DNA damage
| PRJNA113855 | ENA
Project description:Thorium (232Th), an actinoide element, is among the most common and naturally occurring radioactive materials distributed in our environment. Thorium has been used as a radiographic contrast agent (thorotrast) from 1930 to 1955, and many studies on its effects to the human body have been reported. Once thorium is injected in the body, the risk of cancer is increased by the direct bombardment from alpha-particle with high linear energy transfer during decay of Thorium. However, these many reports focus on the irradiation damage by long-term exposure of thorium. The acute toxicity of thorium is greater risk from the chemical toxicity than from the radiological toxicity. Here, we evaluated the effect of thorium from the stand point of chemical toxicity using yeast DNA microarray. In this experiment, genes that contribute to “C-compound and carbohydrate metabolism”, “energy”, and “cell rescue, defense and virulence” were significantly induced. These genes were classified into oxidative stress, glycogen and trehalose metabolism, sugar transport, and cell wall damage. On the contrary, only one gene related to DNA damage was detected. These results indicate that thorium causes the damage of cell wall and induces the oxidative stress. In order to overcome oxidative stress, yeast cells promote the glycogen and trehalose metabolisms and shift to anaerobic fermentation. Keywords: stress response
2007-11-01 | GSE9463 | GEO