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Rattus norvegicus

ABSTRACT: experiment in midbrain primary cultures, enriched in dopaminergic neurons

ORGANISM(S): Rattus norvegicus  



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Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro.

Volpicelli Floriana F   Caiazzo Massimiliano M   Greco Dario D   Consales Claudia C   Leone Luigi L   Perrone-Capano Carla C   Colucci D'Amato Luca L   di Porzio Umberto U  

Journal of neurochemistry 20070515 2

The transcription factor Nurr1 is essential for the generation of midbrain dopaminergic neurons (mDA). Only a few Nurr1-regulated genes have so far been identified and it remains unclear how Nurr1 influences the development and function of dopaminergic neurons. To identify novel Nurr1 target genes we have used genome-wide expression profiling in rat midbrain primary cultures, enriched in dopaminergic neurons, following up-regulation of Nurr1 expression by depolarization. In this study we demonst  ...[more]

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