Genomics,Multiomics

Dataset Information

0

Mus musculus


ABSTRACT: Edema Toxin-treated Macrophage Study

OTHER RELATED OMICS DATASETS IN: E-GEOD-4712

PROVIDER: PRJNA95597 | ENA |

REPOSITORIES: ENA

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Publications

Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin.

Comer Jason E JE   Galindo Cristi L CL   Zhang Fan F   Wenglikowski Autumn M AM   Bush Katie L KL   Garner Harold R HR   Peterson Johnny W JW   Chopra Ashok K AK  

Microbial pathogenesis 20060718 2-3


Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstitial edema seen in anthrax patients. We used GeneChip analysis to examine global transcriptional profiles of EdTx-treated RAW 264.7 murine macrophage-like cells and identified 71 and 259 genes whose exp  ...[more]

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