Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus norvegicus

ABSTRACT: Adjudin-induced germ cell loss from adult rat testes

OTHER RELATED OMICS DATASETS IN: E-GEOD-5131

PROVIDER: PRJNA96637 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Radiation effects on gene expression in rat testes (Rattus norvegicus)

Project description:Analysis of LBNF1 rat testes from controls, containing both somatic and all germ cell types and from irradiated rats in which all cells germ cells except type A spermatgogonia are eliminated. Results provide insight into distinguishing germ and somatic cell genes and identification of somatic cell genes that are upregulated after irradiation.

2009-09-30 | GSE15223 | GEO

Transcription profiling of adult Rattus norvegicus testis at 0, 8 hours and 4 days after Adjudin treatment

Project description:This is a study to explore the transcriptional changes after Adjudin treatment in adult rat testes at three time points (control, 8 hour and 4 day). Adjudin, [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide], is a potential male contraceptive that targets the Sertoli-germ cell interface and causes germ cell depletion from the seminiferous epithelium. Adjudin has been proved to be a useful model to study the mechanisms that regulate junction restructuring in the testis. Experiment Overall Design: Sprague-Dawley rats treated with a single dose of Adjudin at 50 mg/kg b.w. by gavage and terminated after 8 hours (n=2) and 4 days (n=3). Testes from Adjudin-treated rats and untreated (control, n=3) rats were harvested and total RNA were prepared. Standard Affymetrix genechip procedures were followed for the subsequent experiments. Data were analysed in MAS 5.0 and GeneSpring 7.2.

2007-11-29 | E-GEOD-5131 | biostudies-arrayexpress

Rattus norvegicus

Project description:Rat germ cells

| PRJNA87829 | ENA

Hormone effects on gene expression in somatic cells of rat testes (Rattus norvegicus)

Project description:Analysis of hormone effects on irradiated LBNF1 rat testes, which contain only somatic cells except for a few type A spermatgogonia. Rats were treated for 2 weeks with either sham treatment (group X), hormonal ablation (GnRH antagonist and the androgen receptor antagonist flutamide, group XAF), testosterone supplementation (GnRH antagonist and testosterone, group XAT), and FSH supplementation ((GnRH antagonist, androgen receptor antagonist, and FSH, group XAFF). Results provide insight into identifying genes in the somatic testis cells regulated by testosterone, LH, or FSH.

2009-09-30 | GSE15243 | GEO

Transcriptome Profiling of Rattus norvegicus Embryonic Stem Cells by RNA-Sequencing

Project description:In order to establish a rat embryonic stem cell transcriptome, mRNA from rESC cell line DAc8, the first male germline competent rat ESC line to be described and the first to be used to generate a knockout rat model was characterized using RNA sequencing (RNA-seq) analysis.

2016-09-02 | GSE44150 | GEO

Rattus norvegicus

Project description:Radiation effects on gene expression in rat testes (Rattus norvegicus)

| PRJNA116475 | ENA

Rattus norvegicus

Project description:Genomic profiles of oxidative stress-induced rat renal cell carcinomas

| PRJNA152973 | ENA

Rattus norvegicus

Project description:Expression data from adult rat testes treated with 3 mg/kg b.w. cadmium chloride via i.p.

| PRJNA103255 | ENA

Expression data from adult rat testes treated with 3 mg/kg b.w. cadmium chloride via i.p.

Project description:This is a study to explore the transcriptional changes after cadmium treatment in adult rat testes at three time points (control--0 hour, 8 hour and 4 day). Cadmium is an environmental toxicant that is known to affect the male reproductive system. It disrupts the blood-testis barrier irreversibly, and affects the Sertoli-germ cells adhesion, causing germ cell depletion from the seminiferous epithelium. Keywords: Cadmium effect in rat testes

2007-11-07 | GSE9480 | GEO

Rattus norvegicus

Project description:Effect of high fat diet on the rat germ cell transcriptome

| PRJNA319800 | ENA