Dataset Information


Saccharomyces cerevisiae

ABSTRACT: Expression analysis of edc3 cell

ORGANISM(S): Saccharomyces cerevisiae  



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YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA.

Dong Shuyun S   Li Chunfang C   Zenklusen Daniel D   Singer Robert H RH   Jacobson Allan A   He Feng F  

Molecular cell 20070201 4

Autoregulatory loops often provide precise control of the level of expression of specific genes that encode key regulatory proteins. Here we have defined a pathway by which Yra1p, a yeast mRNA export factor, controls its own expression. We show that YRA1 exon 1 sequences in cis and Yra1p in trans inhibit YRA1 pre-mRNA splicing and commit the pre-mRNA to nuclear export. Mex67p and Crm1p jointly promote YRA1 pre-mRNA export, and once in the cytoplasm, the pre-mRNA is degraded by a 5' to 3' decay m  ...[more]

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