Genomics

Dataset Information

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ABSTRACT: Foxp3-dependent programme of regulatory T-cell differentiation

PROVIDER: PRJNA99793 | ENA |

REPOSITORIES: ENA

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Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune responses. Despite its important role, molecular and functional features conferred by Foxp3 to Tr precursor cells remain unknown. It has been suggested that Foxp3 expression is required for both survival of Tr precursors as well as their inability to produce interleukin (IL)-2 and independently proliferate after T-cell-rece  ...[more]

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