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H.sapiens - Cell line, H441, SC (Balbin,nat_commun,2013)

ABSTRACT: abundance based on Spectral counting, H441, Interaction consistency score: 3.0, Coverage: 51

ORGANISM(S): 9606

SUBMITTER: Christian von Mering

PROVIDER: 264215252 | PAXDB | 2013

REPOSITORIES: PAXDB

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			Action	DRS
	bioprojects-abundance-files-v4.0.zip	Other

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Publications

Reconstructing targetable pathways in lung cancer by integrating diverse omics data.

Balbin O Alejandro OA Prensner John R JR Sahu Anirban A Yocum Anastasia A Shankar Sunita S Malik Rohit R Fermin Damian D Dhanasekaran Saravana M SM Chandler Benjamin B Thomas Dafydd D Beer David G DG Cao Xuhong X Nesvizhskii Alexey I AI Chinnaiyan Arul M AM

Nature communications 20130101

Global 'multi-omics' profiling of cancer cells harbours the potential for characterizing the signalling networks associated with specific oncogenes. Here we profile the transcriptome, proteome and phosphoproteome in a panel of non-small cell lung cancer (NSCLC) cell lines in order to reconstruct targetable networks associated with KRAS dependency. We develop a two-step bioinformatics strategy addressing the challenge of integrating these disparate data sets. We first define an 'abundance-score' ...[more]

PMID: 24135919

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