Dataset Information

Tgondii - Whole organism, iBAQ (Kloehnetal,bmcbiol2020)

ABSTRACT: abundance based on iBAQ, Interaction consistency score: 4.8, Coverage: 6

ORGANISM(S): 5811

SUBMITTER: Christian von Mering

PROVIDER: 2899534466 | PAXDB | 2020

REPOSITORIES: PAXDB

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Dataset's files

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			Action	DRS
	bioprojects-abundance-files-v4.0.zip	Other

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Publications

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii.

Kloehn Joachim J Oppenheim Rebecca D RD Siddiqui Ghizal G De Bock Pieter-Jan PJ Kumar Dogga Sunil S Coute Yohann Y Hakimi Mohamed-Ali MA Creek Darren J DJ Soldati-Favre Dominique D

BMC biology 20200616 1

<h4>Background</h4>Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (ACS); ATP citrate lyase (ACL)), mitochondrion (branched-chain α-keto acid dehydrogenase-complex (BCKDH)) and apicoplast (pyruvate dehydrogenase complex (PDH)). Given the dive ...[more]

PMID: 32546260

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