Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

M.aeruginosa - Whole organism, Uwoccmrd, SC (Alexova,mcp,2011)

ABSTRACT: abundance based on Spectral counting UWOCCMRD, UWOCCMRD, Interaction consistency score: 2.3, Coverage: 39

ORGANISM(S): 449447

SUBMITTER: Christian von Mering

PROVIDER: 3141380789 | PAXDB | 2011

REPOSITORIES: PAXDB

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	bioprojects-abundance-files-v4.0.zip	Other

Items per page:

1 - 1 of 1

Publications

Comparative protein expression in different strains of the bloom-forming cyanobacterium Microcystis aeruginosa.

Alexova Ralitza R Haynes Paul A PA Ferrari Belinda C BC Neilan Brett A BA

Molecular & cellular proteomics : MCP 20110524 9

Toxin production in algal blooms presents a significant problem for the water industry. Of particular concern is microcystin, a potent hepatotoxin produced by the unicellular freshwater species Microcystis aeruginosa. In this study, the proteomes of six toxic and nontoxic strains of M. aeruginosa were analyzed to gain further knowledge in elucidating the role of microcystin production in this microorganism. This represents the first comparative proteomic study in a cyanobacterial species. A larg ...[more]

PMID: 21610102

Similar Datasets

M.aeruginosa - Whole organism, Uwocccbs, SC (Alexova,mcp,2011)

Project description:abundance based on Spectral counting UWOCCCBS, UWOCCCBS, Interaction consistency score: 2.2, Coverage: 39

2011-00-00 | 3239272253 | PAXDB

Interactions between Yeast Proteins and Rsp5 Ubiquitin Ligase

Project description:To identify substrates of the ubiquitinating E3 enzyme Rsp5 we applied purified Rsp5 to duplicate protein arrays. The Rsp proteins were expressed as fusion proteins to GST. We used as a control Ubr1, a RING domain containing E3 ligase We analyzed Rsp5 from S.cerevisiae on duplicate arrays, with four control chips, two without Rsp5 and two with Ubr1.

2008-12-30 | E-GEOD-14218 | biostudies-arrayexpress

Salivary cytokine alterations in HIV infection

Project description:This SuperSeries is composed of the following subset Series: GSE24037: Salivary cytokine alterations in HIV infection part 1 GSE24064: Salivary cytokine alterations in HIV infection part 2 Refer to individual Series

2011-09-08 | E-GEOD-24411 | biostudies-arrayexpress

Parity and the genomic signature in the Human Breast

Project description:Case-control study for the analysis of the gene expression profile of epithelial cells microdissected from normal breast tissues obtained from 17 parous and 7 nulliparous women free of breast pathology (controls), and 39 parous and 8 nulliparous women with history of breast cancer (cases). Keywords: genetic modifications Four-condition experiment: nulliparous case, nulliparous control, parous case and parous control labeled with Cy5 and Universal human reference used as a common reference labeled with Cy3. Moderated t statistic was used as the basic statistic for significance analysis; it was computed for each probe and for each contrast. False discovery rate was controlled using the Benjamini and Hochberg. All genes with P value below a threshold of 0.05 were selected as differentially expressed, maintaining the proportion of false discoveries in the selected group below the threshold value, in this case 5%. Breast 11 parous control HuII, Breast 28 parous case HuII, and Breast 62 nulliparous control HuIII excluded: raw data is missing

2008-11-03 | E-GEOD-13293 | biostudies-arrayexpress

Effect of short- and long-term morphine treatment on gene expression in the hypothalamus and pituitary

Project description:Addictive drugs including opioids activate signal transduction pathways that regulate gene expression in the brain. However, changes in CNS gene expression following morphine exposure are poorly understood. We studied the effect of short- and long-term morphine treatment on gene expression in the hypothalamus and pituitary using genome-wide DNA microarray and real-time reverse transcriptase polymerase chain reaction (RT-PCR) analyses. In the hypothalamus, we found that short-term morphine administration up-regulated (at least 2-fold) 39 genes and down-regulated six genes. Long-term morphine administration up-regulated 35 genes and down-regulated 51 hypothalamic genes. In the pituitary, we found that short-term morphine administration up-regulated (at least 2-fold) 110 genes and down-regulated 29 genes. Long-term morphine administration up-regulated 85 genes and down-regulated 37 pituitary genes. Strikingly, microarray analysis uncovered several genes involved in food intake (neuropeptide Y, agouti-related protein, and cocaine and amphetamine-regulated transcript) whose expression was strongly altered by morphine exposure in either the hypothalamus or pituitary. Subsequent RT-PCR analysis confirmed similar gene regulation of noteworthy genes in these regions. Finally, we found functional correlation between morphine-induced alterations in food intake and regulations of genes involved in this process. Changes in genes related to food intake may uncover new pathways related to some of the physiological effects of opioids. Keywords: Comparative treatment versus placebo 8 samples analyzed: 4 from hypothalamus (2 biological replicates and 2 dye swaps) and 4 from pituitary (2 biological replicates and 2 dye swaps) 8 samples analyzed: 4 from hypothalamus short term treatment (2 biological replicates and 2 dye swaps) and 4 hypothalamus long term treatment (2 biological replicates and 2 dye swaps)

2008-09-30 | E-GEOD-9525 | biostudies-arrayexpress

Quantitative Proteomics Reveals Transforming growth factor beta Axis Induced by Resveratrol and Hesperetin Coformulation in Endothelial Cells

Project description:The endothelium is the frontline target of multiple metabolic stressors and pharmacological agents. As a consequence, endothelial cells (ECs) display highly dynamic and diverse proteome profiles. We describe here the culture of human aortic ECs from healthy and type 2 diabetic donors, the treatment with a small molecular conformation of trans-resveratrol and hesperetin (tRES+HESP), followed by proteomic analysis of whole-cell lysate. A number of 3666 proteins were presented in all the samples and thus further analyzed. We found that 179 proteins had a significant difference between diabetic ECs vs. healthy ECs, while 81 proteins had a significant change upon the treatment of tRES+HESP in diabetic ECs. Among them, 16 proteins showed a difference between diabetic ECs and healthy ECs and the difference was reversed by the tRES+HESP treatment, with the top 5 drastically altered proteins being ACVRL1, ADAM9, ITGAV, PCCB, and TGFBR2. Follow-up functional assays identified ACVRL1 and TGFBR2 as the most pronounced mediator for tRES+HESP-induced protection of angiogenesis in vitro. Our study has revealed the global changes in proteins and biological pathways in ECs from diabetic donors, which are potentially reversible by the tRES+HESP formula. Furthermore, we have identified the TGFβ signaling axis as a responding mechanism in ECs treated with this formula, shedding light for future studies for deeper molecular characterization

2023-07-20 | PXD036094 | Pride

M.aeruginosa - Whole organism, Pcc7055, SC (Alexova,mcp,2011)

Project description:abundance based on Spectral counting PCC7055, PCC7055, Interaction consistency score: 2.8, Coverage: 52

2011-00-00 | 4146265595 | PAXDB

M.aeruginosa - Whole organism, Uwoccmrc, SC (Alexova,mcp,2011)

Project description:abundance based on Spectral counting UWOCCMRC, UWOCCMRC, Interaction consistency score: 1.0, Coverage: 35

2011-00-00 | 141330584 | PAXDB

M.aeruginosa - Whole organism, Pcc7806, SC (Alexova,mcp,2011)

Project description:abundance based on Spectral counting PCC7806, PCC7806, Interaction consistency score: 2.6, Coverage: 44

2011-00-00 | 632436410 | PAXDB

Mice with fibrinogen-induced arthritis (FIA)

Project description:This SuperSeries is composed of the following subset Series: GSE18023: Mice with FIA develop anti-native and anti-in vitro citrullinated fibrinogen antibodies GSE18024: FIA plasma induces arthritis in naÃ¯ve mice GSE18025: Fibrinogen-reactive T cells transfer disease to naÃ¯ve mice Refer to individual Series

2010-05-05 | E-GEOD-18073 | biostudies-arrayexpress