Dataset Information

Stuberosum - Leaf, SC (Xiaoetal,intjmolsci.2019)

ABSTRACT: abundance based on Spectral counting, Interaction consistency score: 14.1, Coverage: 15

ORGANISM(S): 4113

SUBMITTER: Christian von Mering

PROVIDER: 3769969026 | PAXDB | 2019

REPOSITORIES: PAXDB

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Dataset's files

Source:

			Action	DRS
	bioprojects-abundance-files-v4.0.zip	Other

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Publications

Quantitative Proteomics of Potato Leaves Infected with Phytophthora infestans Provides Insights into Coordinated and Altered Protein Expression during Early and Late Disease Stages.

Xiao Chunfang C Gao Jianhua J Zhang Yuanxue Y Wang Zhen Z Zhang Denghong D Chen Qiaoling Q Ye Xingzhi X Xu Yi Y Yang Guocai G Yan Lei L Cheng Qun Q Chen Jiaji J Shen Yanfen Y

International journal of molecular sciences 20190101 1

In order to get a better understanding of protein association during Solanum tuberosum (cv. Sarpo Mira)⁻Phytophthora infestans incompatible interaction, we investigated the proteome dynamics of cv. Sarpo Mira, after foliar application of zoospore suspension from P. infestans isolate, at three key time-points: zero hours post inoculation (hpi) (Control), 48 hpi (EI), and 120 hpi (LI); divided into early and late disease stages by the tandem mass tagging (TMT) method. A total ...[more]

PMID: 30609684

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Project description:Progressive supranuclear palsy (PSP) is a neurodegenerative disorder clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism, and cognitive decline caused by degeneration in specific areas of the brain including globus pallidus (GP), substantia nigra, and subthalamic nucleus. However, the pathogenetic mechanism of PSP remains unclear to date. Unbiased global proteome analysis of patients’ brain samples is an important step toward understanding PSP pathogenesis, as proteins serve as workhorses and building blocks of the cell. In this study, we conducted unbiased mass spectrometry-based global proteome analysis of GP samples from 15 PSP patients, 15 Parkinson disease (PD) patients, and 15 healthy control (HC) individuals. To analyze 45 samples, we conducted 5 batches of 11-plex isobaric tandem mass tag (TMT)-based multiplexing experiments, identifying 10,231 proteins. The gene set enrichment analysis results showed that the PD pathway was the most highly enriched, followed by pathways for oxidative phosphorylation, Alzheimer disease, Huntington disease, and non-alcoholic fatty liver disease (NAFLD) when PSP was compared to HC or PD. Most of the proteins enriched in the gene set enrichment analysis were mitochondrial proteins such as cytochrome c oxidase, NADH dehydrogenase, acyl carrier protein, succinate dehydrogenase, ADP/ATP translocase, cytochrome b-c1 complex, and/or ATP synthase. Strikingly, all of the enriched mitochondrial proteins in the PD pathway were downregulated in PSP compared to both HC and PD. The subsequent Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) protein-protein interaction (PPI) analysis and the weighted gene co-expression network analysis (WGCNA) further supported that the mitochondrial proteins were the most highly enriched in PSP. This is the first global proteome analysis of human GP from PSP patients, and this study paves the way to understanding the pathogenesis mechanism of PSP.

Dataset Information

Stuberosum - Leaf, SC (Xiaoetal,intjmolsci.2019)

Dataset's files

Publications

Quantitative Proteomics of Potato Leaves Infected with <i>Phytophthora infestans</i> Provides Insights into Coordinated and Altered Protein Expression during Early and Late Disease Stages.

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