R.norvegicus - Brain, SC (Orietal,cellsyst2015)
Ontology highlight
ABSTRACT:
ORGANISM(S): 10116
SUBMITTER: 
Christian von Mering
PROVIDER: 860274101 | PAXDB | 2015
REPOSITORIES: PAXDB
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| bioprojects-abundance-files-v4.0.zip | Other |
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Publications
Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.
Ori Alessandro A Toyama Brandon H BH Harris Michael S MS Bock Thomas T Iskar Murat M Bork Peer P Ingolia Nicholas T NT Hetzer Martin W MW Beck Martin M
Cell systems 20150917 3
Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins w ...[more]
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