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Yagsn1_1120rpt

ABSTRACT: replicate enrichment for soluble proteins; 1100-2000 m/z; Goo et al., 2003, Mol Cell Proteomics 2(8):506

INSTRUMENT(S): Unknown

ORGANISM(S): Halobacterium Nrc-1 (halobacterium)

SUBMITTER: Y. A. Goo, E. C. Yi, N. S. Baliga, W. A. Tao, M. Pan, R. Aebersold, D. R. Goodlett, L. Hood and W. V. Ng

PROVIDER: PAe000173 | PeptideAtlas | 2011-12-31

REPOSITORIES: PeptideAtlas

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			Action	DRS
	PAe000173_171_search.params.tar.gz	Other
	PAe000173_171_sequest.params	Other
	PAe000173_RAW.tar	Raw
	PAe000173_README	Other
	PAe000173_Search_Results_171_201104181135.properties	Other

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Publications

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

Blasius Melanie M Forment Josep V JV Thakkar Neha N Wagner Sebastian A SA Choudhary Chunaram C Jackson Stephen P SP

Genome biology 20110818 8

<h4>Background</h4>The cell-cycle checkpoint kinase Chk1 is essential in mammalian cells due to its roles in controlling processes such as DNA replication, mitosis and DNA-damage responses. Despite its paramount importance, how Chk1 controls these functions remains unclear, mainly because very few Chk1 substrates have hitherto been identified.<h4>Results</h4>Here, we combine a chemical genetics approach with high-resolution mass spectrometry to identify novel Chk1 substrates and their phosphoryl ...[more]

PMID: 21851590

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