Ontology highlight
ABSTRACT:
INSTRUMENT(S): Unknown
ORGANISM(S): Halobacterium Nrc-1 (halobacterium)
SUBMITTER: Y. A. Goo, E. C. Yi, N. S. Baliga, W. A. Tao, M. Pan, R. Aebersold, D. R. Goodlett, L. Hood and W. V. Ng
PROVIDER: PAe000252 | PeptideAtlas | 2011-12-31
REPOSITORIES: PeptideAtlas
Molecular & cellular proteomics : MCP 20111213 3
Despite the increasing importance of heat shock protein 90 (Hsp90) inhibitors as chemotherapeutic agents in diseases such as cancer, their global effects on the proteome remain largely unknown. Here we use high resolution, quantitative mass spectrometry to map protein expression changes associated with the application of the Hsp90 inhibitor, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG). In depth data obtained from five replicate SILAC experiments enabled accurate quantificatio ...[more]