Proteomics

Dataset Information

0

Yeast_cell_lysate


ABSTRACT: yeast_quality_control

INSTRUMENT(S): LTQ

ORGANISM(S): Saccharomyces Cerevisiae

SUBMITTER: Amanda Paulovich 

PROVIDER: PAe000324 | PeptideAtlas | 2006-12-31

REPOSITORIES: PeptideAtlas

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Publications

Quality control metrics for LC-MS feature detection tools demonstrated on Saccharomyces cerevisiae proteomic profiles.

Piening Brian D BD   Wang Pei P   Bangur Chaitanya S CS   Whiteaker Jeffrey J   Zhang Heidi H   Feng Li-Chia LC   Keane John F JF   Eng Jimmy K JK   Tang Hua H   Prakash Amol A   McIntosh Martin W MW   Paulovich Amanda A  

Journal of proteome research 20060701 7


Quantitative proteomic profiling using liquid chromatography-mass spectrometry is emerging as an important tool for biomarker discovery, prompting development of algorithms for high-throughput peptide feature detection in complex samples. However, neither annotated standard data sets nor quality control metrics currently exist for assessing the validity of feature detection algorithms. We propose a quality control metric, Mass Deviance, for assessing the accuracy of feature detection tools. Beca  ...[more]

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