Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Skeletal_muscle_MUS.TB.5181_4_months_Danish_Landrace_QStarXL

ABSTRACT: biosource.anatomical.site.ontology.entry: EV:0100377 skeletal muscle developmental.stage.ontology.entry: EV:0300042 four months pathology.ontology.entry: EV:0400162

INSTRUMENT(S): QSTAR XL

ORGANISM(S): Sus Scrofa

SUBMITTER:

PROVIDER: PAe000654 | PeptideAtlas |

REPOSITORIES: PeptideAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	PAe000654_README	Other
	PAe000654_Search_Results_9112_201507212230.properties	Other
	PAe000654_Search_Results_9112_201507212230.tar.gz	Other
	PAe000654_prot_9112_201507212230.properties	Other
	PAe000654_prot_9112_201507212230.tar.gz	Other

Items per page:

1 - 5 of 6

Similar Datasets

Identification of FoxO target genes during C-26 cancer cachexia

Project description:Forkhead BoxO (FoxO) transcription factors expressed in adult skeletal muscle promote muscle atrophy during various catabolic conditions. We have identified the genome wide target genes and biological networks regulated by FoxO in skeletal muscle during Colon-26 (C-26) cancer cachexia. In this dataset, we include the expression data obtained from the tibialis anterior muscles of control and severely cachectic Colon-26 mice in which FoxO-dependent transcription was either intact (AAV9-EV) or inhibited (AAV9-d.n.FoxO). These data were used to obtain 543 FoxO target genes during cancer. These target genes were identified as those genes whose expression was both differentially regulated in skeletal muscle in response to cancer (control AAV9-EV vs. C26 AAV9-EV), and differentially regulated in the presence of d.n.FoxO (C26 AAV9-EV vs. C26 AAV9-d.n.FoxO).

2014-12-31 | GSE56555 | GEO

Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis

Project description:How regular physical activity is able to improve health remains poorly understood, but release of substances from skeletal muscle following exercise is one proposed mechanism. Here we describe a novel mechanism through which physical activity initiates extracellular vesicle (EV)-mediated communication between skeletal muscle and adipose tissue causing increased adipocyte lipolysis as a result of enhanced catecholamine sensitivity. In response to a hypertrophic stimulus induced by mechanical overload (MOV), skeletal muscle released EVs containing muscle-specific miR-1 which were preferentially taken up by epididymal white adipose tissue (eWAT) and were associated with elevated adrenergic signaling and lipolysis. Inhibiting EV release by GW4869 treatment prevented the MOV-induced increase in eWAT miR-1 abundance and expression of lipolytic factors. miR-1 was shown to induce adrenergic receptor beta β3 (Adrβ3) expression in adipocytes by targeting transcription factor AP-2, alpha (Tfap2α, a known repressor of Adrβ3 expression. Ex vivo experiments showed enhanced catecholamine sensitivity and elevated fatty acid oxidation in eWAT following MOV. Following a bout of resistance exercise in humans, skeletal muscle miR-1 expression was decreased with a concomitant increase in EV miR-1 abundance, suggesting that a skeletal muscle-adipose tissue axis is operative in humans. Altogether, our highly novel findings demonstrate that skeletal muscle promotes metabolic adaptations in adipose tissue in response to MOV via EV-mediated delivery of miR-1.

2021-05-26 | GSE150162 | GEO

RNA-seq of gastrocnemius (GA) muscle tissue from mice treated with extracellular vesicles (EV) from MCF-10A /miR122 cells

Project description:To detect gene expression changes in skeletal muscle caused by EVs from mMCF-10A/miR-122 cells, we analyzed RNA isolated from the GA muscle of EV-treated female NOD scid gamma (NSG) mice. Mice had received tail-vein injections of EVs twice a week for 5 weeks (~10 ug EV per injection). Gene expression in muscle from mice treated with MCF-10A/miR-122-derived EVs.

2022-01-01 | GSE164303 | GEO

Skeletal_muscle_MUS.MYO005_4_months_Danish_Landrace_QStarElite