Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MAM13

ABSTRACT: Mammary gland_13

INSTRUMENT(S): QSTAR Elite

ORGANISM(S): Bos Taurus

SUBMITTER: Bislev SL, Deutsch EW, Sun Z, Farrah T, Aebersold R, Moritz RL, Bendixen E, Codrea MC

PROVIDER: PAe002049 | PeptideAtlas |

REPOSITORIES: PeptideAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	PAe002049_5488_tandem.params	Other
	PAe002049_README	Other
	PAe002049_Search_Results_5488_201204261831.properties	Other
	PAe002049_Search_Results_5488_201204261831.tar.gz	Other
	PAe002049_mzML_201204261829.properties	Other

Items per page:

1 - 5 of 9

Similar Datasets

Bovine mammary epithelial cells in response to artemisinin treatment

Project description:Bovine mammary epithelial cells in response to artemisinin treatment

2020-09-02 | PXD021269 |

BreastCancer_Control_Micorarays

Project description:Genotyping array data for normal mammary gland control samples

| EGAD00010002250 | EGA

Project description:mammary

| PRJNA885967 | ENA

Tissue Proteomics of Feline Mammary Carcinoma: Different in protein profiles among Histological Grades using Liquid chromatography‑Tandem Mass Spectrometry

Project description:Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis, and therapy selection. This study aims to identify candidate biomarkers for FMC by comparing tissue proteomic profiles among grades of 31 FMC cats and 6 normal mammary tissues (control) using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).

2024-08-13 | PXD054830 | JPOST Repository

BreastCancer_Miroarrays

Project description:Genotyping array data for breast cancer and matched normal mammary gland samples

| EGAD00010002251 | EGA

Uncovering tumor-stroma inter-relationships using quantitative MALDI-Mass spectrometry imaging

Project description:To facilitate analysis of protein expression changes in in situ tumors and stroma, we took advantage of a mouse model that permits conditional activation of the Ser-Thr kinase ROCK within mammary tumor cells. In this study, we undertook MALDI-MSI analysis of tissue samples derived from our conditional ROCK mammary tumor model, to quantify in an unbiased manner, the proteomic changes occurring during the progression of mammary cancers in their specific spatial contexts.

2020-09-07 | PXD019255 | Pride

Bianca2012 - Mathematical modeling of the immune system recognition to mammary carcinoma antigen

Project description:This model describes the humoral and cellular response of the immune system to a tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The model is used to analyze and investigate the competition between immune system cells and mammary carcinoma cells under the action of a vaccine.

2019-11-13 | MODEL1907260002 | BioModels

Temporal Profiling of PyMT Tumour Matrisome during Progression

Project description:In this study, through coupling of our ISDoT tissue decellularisation technology with quantitative mass spectrometry, we explored the changing tumour matrisome during mammary tumourigenesis in the PyMT breast cancer model compared to age-matched healthy control mammary gland

2022-03-30 | MSV000089167 | MassIVE

208a735f-4e85-477c-9249-d889eddd1c2b - samples

Project description:BAM files from RNAseq study from regions of insitu and invasive human mammary ductal disease

| EGAD00001008586 | EGA

SILAC identifies LAD1 as an oncogenic filamin binder regulating actin dynamics in response to EGF and marking aggressive breast tumors

Project description:Mutations mimicking growth factor-induced proliferation and motility characterize aggressive subtypes of mammary tumors. To unravel novel players, we applied phosphoproteomics on untransformed mammary cells, which were pre-stimulated with the epidermal growth factor (EGF). This analysis identified ladinin-1 (LAD1), a hitherto poorly characterized protein, as a phosphor-effector of the EGF-to-ERK pathway. We report that LAD1 is essential for mammary cell proliferation and migration. LAD1 is transcriptionally induced, undergoes phosphorylation by EGF and partly co-localizes with actin stress fibers. Yeast 2-hybrids, proximity ligation and co-immunoprecipitation assays revealed that LAD1 binds with filamins, actin cross-linking proteins. Co-sedimentation analyses attribute to LAD1 a role in actin treadmilling, probably in collaboration with SFN/14-3-3sigma. Depletion of LAD1 led to a decrease in transcripts relevant to cell survival, and inhibited growth of mammary xenografts in an animal model. Furthermore, LAD1 is highly expressed in two aggressive subtypes of breast cancer, as well as predicts poor patient prognosis. This study identifies a new cytoskeletal component essential for cell migration and for the acquisition of oncogenic attributes by human mammary tumors.

2019-11-19 | PXD008100 | Pride