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Mm_mChmC_DynamicReader

ABSTRACT: Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

REANALYSIS of: PXD000143

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus

SUBMITTER: A.H. Smits

PROVIDER: PAe004058 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.

Spruijt Cornelia G CG Gnerlich Felix F Smits Arne H AH Pfaffeneder Toni T Jansen Pascal W T C PW Bauer Christina C Münzel Martin M Wagner Mirko M Müller Markus M Khan Fariha F Eberl H Christian HC Mensinga Anneloes A Brinkman Arie B AB Lephikov Konstantin K Müller Udo U Walter Jörn J Boelens Rolf R van Ingen Hugo H Leonhardt Heinrich H Carell Thomas T Vermeulen Michiel M

Cell 20130221 5

Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC), and adult mouse brain tissue. Readers for these modifications are only partially overlapping, and some readers, such as Rfx proteins, display ...[more]

PMID: 23434322

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