Browse
Submit Data
Databases
API
Help

Dataset Information

13 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

AO-A0JE-01A_A2-A0T2-01A_AN-A0AJ-01A_phospho

ABSTRACT: TCGA Cancer Proteome Study of Breast Tissue, Phospho Enrichment, iTRAQ, AO-A0JE-01A_A2-A0T2-01A_AN-A0AJ-01A

INSTRUMENT(S): QExactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast

DISEASE(S): Breast Carcinoma

SUBMITTER: Nathan J. Edwards

PROVIDER: PAe004807 | PeptideAtlas | 2015-12-31

REPOSITORIES: PeptideAtlas

ACCESS DATA

Json Xml

Publications

The CPTAC Data Portal: A Resource for Cancer Proteomics Research.

Edwards Nathan J NJ Oberti Mauricio M Thangudu Ratna R RR Cai Shuang S McGarvey Peter B PB Jacob Shine S Madhavan Subha S Ketchum Karen A KA

Journal of proteome research 20150504 6

The Clinical Proteomic Tumor Analysis Consortium (CPTAC), under the auspices of the National Cancer Institute's Office of Cancer Clinical Proteomics Research, is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of proteomic technologies and workflows to clinical tumor samples with characterized genomic and transcript profiles. The consortium analyzes cancer biospecimens using mass spectrometry, identifying and quantif ...[more]

PMID: 25873244

Similar Datasets

Pseudomonas sp. AO-1

Project description:Pseudomonas sp. AO-1Genome sequencing and assembly

| PRJNA743418 | ENA

Expression profiling in perinatal Ductus Arteriosus (DA) and Aorta (Ao).

Project description:Compared the gene expression profiles of two contiguous vessels pre and post - birth, namely the Ductus Arteriosus (DA), committed to become a fibrous ligament, and the Aorta (Ao), which conversely takes on a permanent activity. The effect of artificially enhanced O2 tension was analyzed in DA in the pre-birth condition. Keywords: Comparison gene expression

2005-09-13 | GSE3290 | GEO

Cellulomonas citrea strain:AO-9

Project description:Cellulomonas citrea strain:AO-9 Genome sequencing and assembly

| PRJNA565129 | ENA

AO-A0JE-01A_A2-A0T2-01A_AN-A0AJ-01A

Project description:TCGA Cancer Proteome Study of Breast Tissue, iTRAQ, AO-A0JE-01A_A2-A0T2-01A_AN-A0AJ-01A

2015-12-31 | PAe004796 | PeptideAtlas

Recurrent TCF12 mutations in anaplastic oligodendroglioma

Project description:A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net: Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable with few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome and/or transcriptome sequencing identifying previously reported frequent somatic mutations in CIC and FUBP1 genes. We also identified recurrent mutations in TCF12 (11% of IDHmut-codel) which encodes basic helix-loop-helix (bHLFH) transcription factor 12 which is an oligodendrocyte-related transcription factor in IDHmut-codel tumors. Strikingly, the somatic mutations (encoding E548R and R602M substitutions) have not been reported previously in cancer but are identical to germline mutations causing craniosynostosis. Incorporating TCGA data on 43 AO tumors also implicates functional mutation of SMARCA4, NOTCH1, NOTCH2, SETD2, RBPJ and ARID1A/1B. These data are compatible with the combined deregulation of metabolism, chromatin organization/remodeling and Notch-pathway genes in AO oncogenesis. Our analysis provides further insights into the unique and shared pathways driving AO and new targets for therapeutic intervention.

2015-06-15 | E-MTAB-2767 | biostudies-arrayexpress

An expression profiling study of anaplastic oligodendroglioma

Project description:A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net): Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable with few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome and/or transcriptome sequencing identifying previously reported frequent somatic mutations in CIC and FUBP1 genes. We also identified recurrent mutations in TCF12 (11% of IDHmut-codel) which encodes basic helix-loop-helix (bHLFH) transcription factor 12; which is an oligodendrocyte-related transcription factor in IDHmut-codel tumors. Strikingly, the somatic mutations (encoding E548R and R602M substitutions) have not been reported previously in cancer but are identical to germline mutations causing craniosynostosis. Incorporating TCGA data on 43 AO tumors also implicates functional mutation of SMARCA4, NOTCH1, NOTCH2, SETD2, RBPJ and ARID1A/1B. These data are compatible with the combined deregulation of metabolism, chromatin organization/remodeling and Notch-pathway genes in AO oncogenesis. Our analysis provides further insights into the unique and shared pathways driving AO and new targets for therapeutic intervention.

2015-07-23 | E-MTAB-2768 | biostudies-arrayexpress

Genotyping by array of anaplastic oligodendroglioma

2015-07-23 | E-MTAB-3457 | biostudies-arrayexpress

AO-A12D-01A_AN-A04A-01A_BH-A0AV-01A_phospho

Project description:TCGA Cancer Proteome Study of Breast Tissue, Phospho Enrichment, iTRAQ, AO-A12D-01A_AN-A04A-01A_BH-A0AV-01A

2015-12-31 | PAe004769 | PeptideAtlas

Recurrent TCF12 mutations in anaplastic oligodendroglioma (Part II, genotyping by array)

Project description:A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net); Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable with few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome and/or transcriptome sequencing identifying previously reported frequent somatic mutations in CIC and FUBP1 genes. We also identified recurrent mutations in TCF12 (11% of IDHmut-codel) which encodes basic helix-loop-helix (bHLFH) transcription factor 12 A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net); which is an oligodendrocyte-related transcription factor in IDHmut-codel tumors. Strikingly, the somatic mutations (encoding E548R and R602M substitutions) have not been reported previously in cancer but are identical to germline mutations causing craniosynostosis. Incorporating TCGA data on 43 AO tumors also implicates functional mutation of SMARCA4, NOTCH1, NOTCH2, SETD2, RBPJ and ARID1A/1B. These data are compatible with the combined deregulation of metabolism, chromatin organization/remodeling and Notch-pathway genes in AO oncogenesis. Our analysis provides further insights into the unique and shared pathways driving AO and new targets for therapeutic intervention.

2015-06-15 | E-MTAB-2771 | biostudies-arrayexpress

Recurrent TCF12 mutations in anaplastic oligodendroglioma (Part III, genotyping by array)

2015-08-15 | E-MTAB-2772 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data