Proteomics

Dataset Information

0

Hs_BreastCancer

ABSTRACT: Proteomic portrait of human breast cancer progression identifies novel prognostic markers

REANALYSIS of: PXD000309

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast

SUBMITTER: Geiger T, Madden SF, Gallagher WM, Cox J, Mann M 

PROVIDER: PAe004809 | PeptideAtlas | 2012-12-31

REPOSITORIES: PeptideAtlas

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Publications

Proteomic portrait of human breast cancer progression identifies novel prognostic markers.

Geiger Tamar T   Madden Stephen F SF   Gallagher William M WM   Cox Juergen J   Mann Matthias M  

Cancer research 20120313 9

Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify proteins that are associated with the progression of ER(-) tumors. Our two-step approach included an initial deep analysis of cultured cells that were obtained from tumors of defined br  ...[more]

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