Proteomics

Dataset Information

150

AA-3989-01A-22


ABSTRACT: Human Colorectal Cancer (AA-3989-01A-22)

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Digestive System

SUBMITTER: Daniel C. Liebler 

PROVIDER: PAe004929 | PeptideAtlas | 2014-12-31

REPOSITORIES: PeptideAtlas

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Publications


Extensive genomic characterization of human cancers presents the problem of inference from genomic abnormalities to cancer phenotypes. To address this problem, we analysed proteomes of colon and rectal tumours characterized previously by The Cancer Genome Atlas (TCGA) and perform integrated proteogenomic analyses. Somatic variants displayed reduced protein abundance compared to germline variants. Messenger RNA transcript abundance did not reliably predict protein abundance differences between tu  ...[more]

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