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Hs_ErbB_Network

ABSTRACT: Human ErbB network proteins in three cell types

REANALYSIS of: PXD000623

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Others

SUBMITTER: Kiel C, Ebhardt HA, Burnier J, Portugal C, Sabid� E, Zimmermann T, Aebersold R, Serrano L

PROVIDER: PAe005020 | PeptideAtlas | 2014-12-31

REPOSITORIES: PeptideAtlas

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Quantification of ErbB network proteins in three cell types using complementary approaches identifies cell-general and cell-type-specific signaling proteins.

Kiel Christina C Ebhardt H Alexander HA Burnier Julia J Portugal Claire C Sabidó Eduard E Zimmermann Timo T Aebersold Ruedi R Serrano Luis L

Journal of proteome research 20131209 1

Relating protein concentration to cell-type-specific responses is one of the remaining challenges for obtaining a quantitative systems level understanding of mammalian signaling. Here we used mass-spectrometry (MS)- and antibody-based quantitative proteomic approaches to measure protein abundances for 75% of a hand-curated reconstructed ErbB network of 198 proteins, in two established cell types (HEK293 and MCF-7) and in primary keratinocyte cells. Comparison with other quantitative studies allo ...[more]

PMID: 24313378

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