Proteomics

Dataset Information

0

Mm_macrophages_silac_R2

ABSTRACT: RAW 264.7 macrophages monolayer; Silac labeled; Replicate 2

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Mus Musculus

SUBMITTER: Anja Freiwald, Christopher Weidner, Annabell Witzke, Sheng-Yu Huang, David Meierhofer and Sascha Sauer 

PROVIDER: PAe005145 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Publications

Comprehensive proteomic data sets for studying adipocyte-macrophage cell-cell communication.

Freiwald Anja A   Weidner Christopher C   Witzke Annabell A   Huang Sheng-Yu SY   Meierhofer David D   Sauer Sascha S  

Proteomics 20131201 23-24

Cellular communication is a fundamental process in biology. The interaction of adipocytes with macrophages is a key event in the development of common diseases such as type 2 diabetes. We applied an established bilayer cell co-culture system and comprehensive mass spectrometry analysis to detect proteome-wide the paracrine interaction of murine adipocytes and macrophages. Altogether, we identified 4486 proteins with at least two unique peptides of which 2392 proteins were informative for 3T3-L1  ...[more]