Proteomics

Dataset Information

86

Hs_PFrontalCortex_Silac


ABSTRACT: Human postmortem frontal cortex proteome

REANALYSIS of: PXD000004

INSTRUMENT(S): QExactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Brain

SUBMITTER: MacDonald ML, et al.    

PROVIDER: PAe005153 | PeptideAtlas | 2012-12-31

REPOSITORIES: PeptideAtlas

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Publications

Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissue.

MacDonald Matthew L ML   Ciccimaro Eugene E   Prakash Amol A   Banerjee Anamika A   Seeholzer Steven H SH   Blair Ian A IA   Hahn Chang-Gyu CG  

Molecular & cellular proteomics : MCP 20120831 12


Synaptic architecture and its adaptive changes require numerous molecular events that are both highly ordered and complex. A majority of neuropsychiatric illnesses are complex trait disorders, in which multiple etiologic factors converge at the synapse via many signaling pathways. Investigating the protein composition of synaptic microdomains from human patient brain tissues will yield valuable insights into the interactions of risk genes in many disorders. These types of studies in postmortem t  ...[more]

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