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HBPP_MultipleSclerosis_Phos

ABSTRACT: HBPP_MultipleSclerosis_Phospho

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH

PROVIDER: PAe005154 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Garris Christopher S CS Wu Linfeng L Acharya Swati S Arac Ahmet A Blaho Victoria A VA Huang Yingxiang Y Moon Byoung San BS Axtell Robert C RC Ho Peggy P PP Steinberg Gary K GK Lewis David B DB Sobel Raymond A RA Han David K DK Steinman Lawrence L Snyder Michael P MP Hla Timothy T Han May H MH

Nature immunology 20130929 11

Sphingosine 1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs into systemic circulation. The sphingosine phosphate receptor 1 (S1P1) agonist FTY-720 (Gilenya) arrests immune trafficking and prevents multiple sclerosis (MS) relapses. However, alternative mechanisms of S1P-S1P1 signaling have been reported. Phosphoproteomic analysis of MS brain lesions revealed S1P1 phosphorylation on S351, a residue crucial for receptor internalization. Mutant mice harboring an S1pr1 ge ...[more]

PMID: 24076635

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