Dataset Information
Hs_U1snRNP_AD
Ontology highlight
ABSTRACT:
REANALYSIS of: PXD000067
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: Bai B, et al.
PROVIDER: PAe005157 | PeptideAtlas | 2013-12-31
REPOSITORIES: PeptideAtlas
Publications
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 20130910 41
Deposition of insoluble protein aggregates is a hallmark of neurodegenerative diseases. The universal presence of β-amyloid and tau in Alzheimer's disease (AD) has facilitated advancement of the amyloid cascade and tau hypotheses that have dominated AD pathogenesis research and therapeutic development. However, the underlying etiology of the disease remains to be fully elucidated. Here we report a comprehensive study of the human brain-insoluble proteome in AD by mass spectrometry. We identify 4 ...[more]
