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Hs_platelets_Phospho_PLPC

ABSTRACT: Human platelets Phospho proteome, treated with PLPC

REANALYSIS of: PXD000451

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Platelet

SUBMITTER: Bjoern Titz

PROVIDER: PAe005239 | PeptideAtlas | 2014-12-31

REPOSITORIES: PeptideAtlas

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Publications

Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.

Zimman Alejandro A Titz Bjoern B Komisopoulou Evangelia E Biswas Sudipta S Graeber Thomas G TG Podrez Eugene A EA

PloS one 20140106 1

Specific oxidized phospholipids (oxPCCD36) promote platelet hyper-reactivity and thrombosis in hyperlipidemia via the scavenger receptor CD36, however the signaling pathway(s) induced in platelets by oxPCCD36 are not well defined. We have employed mass spectrometry-based tyrosine, serine, and threonine phosphoproteomics for the unbiased analysis of platelet signaling pathways induced by oxPCCD36 as well as by the strong physiological agonist thrombin. oxPCCD36 and thrombin induced differential p ...[more]

PMID: 24400094

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