Proteomics

Dataset Information

0

ITRAQ_TMT_Comparison_TMT6


ABSTRACT: IgY14/Supermix depletion, TMT6

INSTRUMENT(S): QExactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Plasma Non-glyco

SUBMITTER: Steve Carr 

PROVIDER: PAe005316 | PeptideAtlas | 2015-12-31

REPOSITORIES: PeptideAtlas

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Publications

Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.

Keshishian Hasmik H   Burgess Michael W MW   Gillette Michael A MA   Mertins Philipp P   Clauser Karl R KR   Mani D R DR   Kuhn Eric W EW   Farrell Laurie A LA   Gerszten Robert E RE   Carr Steven A SA  

Molecular & cellular proteomics : MCP 20150227 9


We have developed a novel plasma protein analysis platform with optimized sample preparation, chromatography, and MS analysis protocols. The workflow, which utilizes chemical isobaric mass tag labeling for relative quantification of plasma proteins, achieves far greater depth of proteome detection and quantification while simultaneously having increased sample throughput than prior methods. We applied the new workflow to a time series of plasma samples from patients undergoing a therapeutic, "pl  ...[more]

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