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Hs_EndothelialCell_Phospho_Silac

ABSTRACT: hosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells

REANALYSIS of: PXD000597

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Plasma Non-glyco

SUBMITTER: van den Biggelaar M, et al.

PROVIDER: PAe005425 | PeptideAtlas | 2014-12-31

REPOSITORIES: PeptideAtlas

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Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells.

van den Biggelaar Maartje M Hernández-Fernaud Juan Ramon JR van den Eshof Bart L BL Neilson Lisa J LJ Meijer Alexander B AB Mertens Koen K Zanivan Sara S

Blood 20140205 12

Thrombin is the key serine protease of the coagulation cascade and a potent trigger of protease-activated receptor 1 (PAR1)-mediated platelet aggregation. In recent years, PAR1 has become an appealing target for anticoagulant therapies. However, the inhibitors that have been developed so far increase bleeding risk in patients, likely because they interfere with endogenous PAR1 signaling in the endothelium. Because of its complexity, thrombin-induced signaling in endothelial cells has remained in ...[more]

PMID: 24501219

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