Proteomics

Dataset Information

0

CFT_pH4-7_R1

ABSTRACT: Doubly depleted pooled plasma; 3 peptide IPG-IEF strips; 24 fractions; pH4-7_R14-7_R2

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Plasma Non-glyco

SUBMITTER: Tan SH, Mohamedali A, Kapur A, Baker MS 

PROVIDER: PAe005429 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Publications

Ultradepletion of human plasma using chicken antibodies: a proof of concept study.

Tan Sock-Hwee SH   Mohamedali Abidali A   Kapur Amit A   Baker Mark S MS  

Journal of proteome research 20130516 6

Human plasma arguably represents the most comprehensive version of the human proteome. Despite its immense theoretical discovery potential, plasma has many high and medium abundance proteins that mask low abundance protein disease biomarkers of relevance, making the discovery of novel diagnostic markers particularly difficult. Some form of protein depletion and/or fractionation is essential in order to detect markers of low abundance. Here, we describe a "proof of concept" two-pronged approach t  ...[more]